possible cure for aids

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PyrotheClown -> possible cure for aids (7/8/2009 10:49:48 PM)
The possible cure for aids as it turns out, is a bone marrow transplant.... Don't know if there was already a thread on this subject from earlier, but thought I would share.

sirsholly -> RE: possible cure for aids (7/9/2009 3:14:57 AM)
quote: ORIGINAL: PyrotheClown The possible cure for aids as it turns out, is a bone marrow transplant.... Don't know if there was already a thread on this subject from earlier, but thought I would share. yet another reason to consider getting on the bone marrow donation list. It saves lives!!

beargonewild -> RE: possible cure for aids (7/9/2009 6:06:42 AM)
quote: ORIGINAL: sirsholly quote: ORIGINAL: PyrotheClown The possible cure for aids as it turns out, is a bone marrow transplant.... Don't know if there was already a thread on this subject from earlier, but thought I would share. yet another reason to consider getting on the bone marrow donation list. It saves lives!! Yes that does look promising and I sure hope that this procedure proves to be one viable solution. Though there is one huge glitch Holly, it is a sad fact that for millions of us, we are banned from being on any donor list simply because of the fact that we have or had sex with another male. That also include us who can prove that our blood is clean. I am not allowed donate blood I am not allowed to be an organ donor I am not allowed to be a bone marrow donor.

samboct -> RE: possible cure for aids (7/9/2009 6:12:27 AM)
AIDS research in this country is a disaster. No, it hasn't been a conspiracy to kill off gays- at least not since the Reagan days where the public health response threw everything we knew about sexually transmitted diseases out the window, but the research into AIDS cures or treatments has followed a very narrow path, i.e. vaccine development which hasn't worked in two dozen years- and that has been a very political decision. There's a little company in CT which has been struggling to commercialize a very different approach to the disease, but which hasn't gotten a lot of traction. Feel free to check them out- www.nanoviricides.com. Sam

slaveboyforyou -> RE: possible cure for aids (7/9/2009 6:19:30 AM)
quote: it is a sad fact that for millions of us, we are banned from being on any donor list simply because of the fact that we have or had sex with another male. How do they find out unless you tell them? Don't tell them; what are they going to do to you if they find out?

beargonewild -> RE: possible cure for aids (7/9/2009 6:21:00 AM)
I know that I sometimes wonder if the medical experts are trying as hard as they say to find a viable cure. Even here in Canada, the damn gov't meeds to open up their small mindedness and put a greater effort into developing a cure(s) for AIDS which hits all walks of life from new born to the elderly.

beargonewild -> RE: possible cure for aids (7/9/2009 6:22:15 AM)
quote: ORIGINAL: slaveboyforyou quote: it is a sad fact that for millions of us, we are banned from being on any donor list simply because of the fact that we have or had sex with another male. How do they find out unless you tell them? Don't tell them; what are they going to do to you if they find out? Granted many probably do lie on the forms that you fill out before donating blood. The few who are caught, face criminal charges.

Rule -> RE: possible cure for aids (7/9/2009 6:24:02 AM)
HIV infects many other tissues besides bone marrow. However, a functioning immune system will defeat such infections of other tissues. Hm, there ought to be various hypothetical ways to limit infection of healthy cells and to combat the infected cells. I can think of some.

slaveboyforyou -> RE: possible cure for aids (7/9/2009 6:28:03 AM)
quote: The few who are caught, face criminal charges. Wow, I didn't know you could be charged with something. I've lied about past drug use on job applications and other forms (I won't say which forms [:D]). Everytime I get asked about marijuana; I say, "No Sir/Ma'am, not me, never. (I try to look like a good, church going boy" They try and get you to admit it, because they know most people under the age of 60 have tried it at least once. I still don't back down. I sure the fuck don't admit to LSD, ecstacy, and 'shrooms. You don't ever admit to taking a hallucinogen, not even a one time use. It excludes you from all sorts of shit. But hell, they can't prove I ever took any of that.

Rule -> RE: possible cure for aids (7/9/2009 6:46:21 AM)
quote: ORIGINAL: beargonewild I know that I sometimes wonder if the medical experts are trying as hard as they say to find a viable cure. I do wonder how many biochemists and immunologists and molecular biologists do meet unfortunate deaths. Anyone keeping track?

LadyAyla7053 -> RE: possible cure for aids (7/9/2009 6:48:37 AM)
Being one that is infected with HIV I would take that with a grain of salt. It would be truly wonderful if a cure was discovered, but you have to realize something. The virus not only attacks the blood but it also attached it self to all cells in the body. Believe me when I was first diagnosed I asked the silly question about a complete blood transfusion. At the time I thought it only affected the blood. As for the bone marrow transplant in the article it said that the person had to quit taking his hiv meds his immune system was destroyed with radiation and he had to take even more powerful drugs. For some of us on hiv medicine taking us off it is quite literally a death sentence. On top of that his doctor, Dr. Huetter isn't an infectious disease specialist but a hemotoligist. So until a cure is found everytime my doctor asks if she can do anything else I'm still going to tell her, "find a cure" continue my medicine and live everyday like it's my last. Bright Blessings everyone...

MstrPBK -> RE: possible cure for aids (7/9/2009 6:49:32 AM)
Yea Bone Marrow transplants seem to be hopeful signs, and (not sure which one it is there are several forms) but there also seems to be growing evidence of Chemotherapy (as in cancer) seems to have significant impact on HIV/AIDS. The verdict is still out on this one; but evidence again suggests something very very promising. At one time (not sure where the research is on this) there were discussions that maybe a simple electrical charge run through the body was enough to out it off balance for other treatments to be MORE effective. I am willing to stick my head out and say HIV/AIDS will be fully subdued by the time I die (notes to room that i am 51 years young and my family lives tiill the late 80's to early 90's). MstrPBK St. Paul, MN USA

LadyAyla7053 -> RE: possible cure for aids (7/9/2009 6:54:53 AM)
Hooray!!! Cured in my lifetime!! I keep hoping and praying let's hope you are correct. Would be simply wonderful....

beargonewild -> RE: possible cure for aids (7/9/2009 7:38:28 AM)
quote: ORIGINAL: MstrPBK I am willing to stick my head out and say HIV/AIDS will be fully subdued by the time I die (notes to room that i am 51 years young and my family lives tiill the late 80's to early 90's). MstrPBK St. Paul, MN USA I sure hope that your prediction is 1000% accurate as I have a couple close friends who have been battling this for many years and I would love to share a few beers with them in 30 or 40 years from now!

DomKen -> RE: possible cure for aids (7/9/2009 8:00:47 AM)
The problem with this treatment is that it requires a bone marrow donor with the HIV resistance mutation which is reasonably rare. So you would need a donor who both has the right mutation but is also a close tissue match. That's just not that likely. Furthermore full body radiation and bone marrow transplants are themselves lethal in a fair number of cases. Finally those with HIV would be simply be trading one set of meds, antiretrovirals, for another, anti rejection drugs.

Caius -> RE: possible cure for aids (7/9/2009 8:53:45 AM)
quote: ORIGINAL: samboct AIDS research in this country is a disaster. No, it hasn't been a conspiracy to kill off gays- at least not since the Reagan days where the public health response threw everything we knew about sexually transmitted diseases out the window, but the research into AIDS cures or treatments has followed a very narrow path, i.e. vaccine development which hasn't worked in two dozen years- and that has been a very political decision. There's a little company in CT which has been struggling to commercialize a very different approach to the disease, but which hasn't gotten a lot of traction. Feel free to check them out- www.nanoviricides.com. Sam I don't know that's entirely fair to classify it as a disaster; the U.S. does in fact lead the world in AIDS research funding by a significant margin and has played host to (or played an important collaborative role in) the vast majority of significant research findings over the last couple of decades. Please note that this should not be taken as an endorsement of the notion that everything is being done that can be done (which is a laughable notion) or a denial that we (and indeed the entire industrial world) have had a rather sordid history when it comes to the public response to this epidemic. But the label of disaster strikes me a bit as an undue slap in the face to the many researchers who have devoted their lives to this cause and have drastically increased the life expectancies of those infected with HIV. Well, those who have access to their treatments anyway; the biggest problem in the medical response to AIDS at present is not making research gains but rather bringing the treatments that have been developed to those who need it. Now, as to the company whose site you linked to, neither their own site nor any press related to them that I've been able to find suggests that they are anything more than a speculative collaboration at present. The actual substance of their product development seems pretty thin, so far.

sirsholly -> RE: possible cure for aids (7/9/2009 8:58:54 AM)
quote: Finally those with HIV would be simply be trading one set of meds, antiretrovirals, for another, anti rejection drugs. Ken...i am pretty sure anti rejection drugs are not an issue with bone marrow transplants (i could be wrong though). The main problem is infection due to the drastically lowered immune system, so the recipients are on heavy doses of antibiotics.

Rule -> RE: possible cure for aids (7/9/2009 9:03:54 AM)
quote: ORIGINAL: sirsholly i am pretty sure anti rejection drugs are not an issue with bone marrow transplants (i could be wrong though). The main problem is infection due to the drastically lowered immune system, so the recipients are on heavy doses of antibiotics. The immune system is down because of the anti-rejection drugs. That is the big problem. If ever I needed a transplant, I would rather choose to honorably die in battle.

sirsholly -> RE: possible cure for aids (7/9/2009 9:08:01 AM)
quote: ORIGINAL: Rule quote: ORIGINAL: sirsholly i am pretty sure anti rejection drugs are not an issue with bone marrow transplants (i could be wrong though). The main problem is infection due to the drastically lowered immune system, so the recipients are on heavy doses of antibiotics. The immune system is down because of the anti-rejection drugs. That is the big problem. If ever I needed a transplant, I would rather choose to honorably die in battle. i thought the immune system was down because the current bone marrow (ie white cells) was destroyed prior to the transplant. And Rule...it is sad that some transplants honorably die in battle, but many do well

Rule -> RE: possible cure for aids (7/9/2009 9:22:31 AM)
quote: ORIGINAL: sirsholly i thought the immune system was down because the current bone marrow (ie white cells) was destroyed prior to the transplant. In transplantation there are two immunology problems: a. host versus graft rejection. In that case there are host immune cells that attack graft cells. Anti-rejection drugs will inactivate the host immune cells and thus will cause extreme vulnerability against any disease, especially virusses and cancer. b. graft versus host rejection. Immune cells from the donor attack host tissues. Again anti-rejection drugs will inactivate all immune cells, both from the host - preventing a - and from the graft, preventing b. Causing again extreme vulnerability against any disease, especially virusses and cancer. This type of rejection in the case of leukemia indeed requires complete annihilation of the host immune system, but it does require a graft immune cell transplant. If a B-cell leukemia, conceivably host T immune cells might be saved outside of the body during radiation, but when reinfused still rejection of graft B-cells might occur.

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